Preheat your oven to 400 degrees Fahrenheit. Arrange your beef bones on a large baking sheet.
Roast beef bones for 30-35 minutes on the top oven rack.
Add roasted beef bones (along with drippings from the pan), 3 tablespoons of apple cider vinegar, 16 cups of filtered water, and 1 teaspoon of salt to your Instant Pot (I used an 8-quart model; reduce the amount of water if using a 6-quart to ensure you don’t go over the max fill line).
Seal the lid and set your Instant Pot to High Pressure cook for 2 hours. The Instant Pot will take around 30 minutes to begin cooking.
When the 2 hours are up, leave it alone for 90 minutes to naturally release the pressure. If you want to hurry up the process, release after 30-45 minutes (there will still be a significant amount of pressure to let off).
Fill your sink with ice. Remove the interior pot from your Instant Pot and nestle in the ice. For safety reasons, it’s best to cool off your bone broth as quickly as possible.
Once cool, transfer the beef bone broth to lidded containers (like Mason jars) for storage. Strain over a fine-mesh sieve to filter the bones and other chunks out. I prefer to finish chilling in the refrigerator, then skim the solidified fat off the top before deciding the beef bone broth's final destination - fridge or freezer.
Store the beef bone broth in the refrigerator for up to five days or freeze for up to three months.